Endocrine Abstracts

Objectives: Aberrances in expression and sequence of miR-146a have a well-established role in pathogenesis of papillary thyroid carcinoma (PTC). The G/C heterozygosity in rs2910164 of miR-146a underlies genetic predisposition to PTC and occurs as a somatic mutation in thyroid tumors. Deleterious function of rs2910164 consists in creation of a new variant of microRNA, resulting from the fact that a single microRNA precursor gives rise to −5p and −3p microRNAs. The S...

Objectives: Papillary thyroid carcinoma (PTC) exhibits aberrant expression of retinoic acid receptor β (RARβ), a retinoic acid-inducible transcription factor, essential for cellular growth and development. The mechanisms leading to decreased RARβ expression in tumors are unknown. We hypothesized that changes in expression of RARB, a gene encoding for RARβ, result from aberrant expression of microRNAs. We elucidated the miRNome of normal thyroid and...